Do baseline correction in origin pro 8 free#
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Received: DecemAccepted: Published: July 2, 2021 (2021) Natural history of disease in cynomolgus monkeys exposed to Ebola virus Kikwit strain demonstrates the reliability of this non-human primate model for Ebola virus disease. Taken together, these factors suggest that the cynomolgus monkey is a reliable animal model for human disease.Ĭitation: Niemuth NA, Fallacara D, Triplett CA, Tamrakar SM, Rajbhandari A, Florence C, et al. Increased liver enzymes were observed shortly after exposure. Changes in leukocyte profiles were indicative of an acute inflammatory response. Changes associated with coagulation parameters and platelets were consistent with coagulation disruption. Hematology indices were indicative of viremia and the propensity for hemorrhage with progression of Ebola viremia. Viremia was detected within a few days of infection. Moderate clinical signs were observed 4 to 5 days after exposure and preceded death or euthanasia by approximately one day. Despite significant differences attributed to exposure variables, all CMs exposed to the 100 to 1,000 pfu doses commonly used in vaccine studies died or met euthanasia criteria within 21 days of exposure, median 7 days, 93% between 5 and 12 days of exposure. Time to death was modeled using Cox proportional hazards models with a frailty term that incorporated study-to-study variability. CMs were exposed to EBOV doses of 0.1 to 100,000 PFU in 33 studies conducted at three Animal Biosafety Level 4 facilities, by three exposure routes.
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This study describes a large CM database (122 CM, 62 female and 60 male, age 2 to 9 years) and demonstrates the consistency of the CM model through time to death models and descriptive statistics.
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To the best of our knowledge, however, animal model development data supporting the use of CM in vaccine research have not been submitted to the FDA. Multiple vaccine candidates have been evaluated using cynomolgus monkeys (CM) exposed to EBOV Kikwit strain. Except in outbreak settings, vaccines and other medical countermeasures against Ebola virus (EBOV) will require testing under the FDA Animal Rule. Filoviruses (Family Filoviridae genera Ebolavirus and Marburgvirus) are negative-stranded RNA viruses that cause severe health effects in humans and non-human primates, including death.